The ultimate bioweapon, scientists have developed an Extinction Gene

Posted by Conspiracy Cafe on July 21, 2017

8th December 2016 Matthew Griffin

WHY THIS MATTERS IN BRIEF

Scientists now have the knowledge and the tools they need to create, and deliver, Doomsday genes which can selectively target and exterminate entire species

Here’s a question that occurs only to madmen and geneticists…

How do you get a gene that kills a species to spread through a whole population?

You can either make your gene deadly, and therefore impossible to pass on, or not – and make it useless. The solution in the past has been to try to create what are known as “silent” genes that can spread throughout a population with no negative side effects, for example, either introducing a deadly weakness to a man made chemical into a species genome, or creating dormant but deadly genes that can be activated when the right trigger presents itself.

Recently, with the advent of advanced new in vivo gene editing technology, it’s become possible to make genes that seem to defy evolution – and that means we could soon start releasing animals carrying doomsday, or, extinction genes, that spread with astonishing speed and which eventually kill off an entire species, or even entire ecosystems.

It sounds like the stuff of science fiction and nightmares, and many argue that that is where this type of technology should stay.

However, such an animal exists, and it’s currently sitting in a laboratory at Imperial College London. An apocalyptic mosquito carrying a gene that could one day end its entire species. It represents a controversial proposal to end the scourge of Malaria, which kills hundreds of thousands of people each and every year, by wiping out the mosquitoes that spread the disease. It also represents a fundamentally new ability for humanity – the power to easily and selectively snuff out an entire subcategory of life on Earth. And the new name for this technology? Gene Drive.

Sounds rather benign doesn’t it? Except for the fact, when combined with an extinction gene, which for example, in this case introduces sterility into an entire population, it’s anything but.

Gene Drive is a methodology that artificially increases a gene’s inheritance rate – these are found throughout nature, but despite decades of theorising, nobody, until now, and spurred on by the advent of CRISPR, a revolutionary gene editing technique that’s also goes under the moniker of the “Genesis Engine“, had a viable way to harness it.

CRISPR and Gene Editing 101

https://www.youtube.com/watch?v=1VaG3DpFXjs

CRISPR’s “molecular scissors” are actually borrowed from viruses, allowing scientists to swap out one gene in a living organism for another gene, for example a doomsday gene, of their choice, and if you can get your gene spliced into the germ cells of a species then you can guarantee that the new trait will be passed down through the generations – classically, without Gene Drive, you can introduce only a 50% chance.

The chance is 50% because germ cells, like virtually all other cell types in humans and mosquitoes, have two copies of our genome, so when scientists splice in their attack gene, it will end up sitting across from a second, totally normal copy of the gene it just replaced. This means that when the two copies get pulled apart to form the half-genomes of two new, separate sperm cells, only one of those new sperm cells will have the spliced in sequence. The other will carry the same gene it would have, regardless.

So, if the spliced in gene lowers “evolutionary fitness”, then all that will happen is the other half of the offspring will thrive, and, as a result the infected “genetically crippled” individuals will be quickly bred out of the population.

Imperial College’s doomsday mosquito gets around these problems by applying two innovations.

First, it forces itself into 99% of a mosquito’s sperm cells, and thus into 99% of its offspring. It can do this by exploiting the natural process of the genomes proof reading abilities. Once the synthetic gene has been spliced in to replace a target gene, scientists can design the system to intentionally damage the other, natural copy of that target gene. Do enough damage and the cell’s machinery shows up to repair it back to normal. But what’s normal? Well, the DNA double helix provides a template and the repair enzymes end up using the spliced in gene as the guide for what the “natural version” is supposed to look like.

Once the natural version of our gene has been “repaired” into the engineered version, both alleles, or copies, of the gene have the new man made sequence. Now, when the germ cell divides into two sperm cells, both those sperm cells get the modified version of the gene. So now, no matter which of those sperm cells goes on to fertilize an egg, the resulting mosquito will inherit the inserted attack gene. And the germ cells of those offspring get the Gene Drive effect, carrying it on to the next generation, and the next, and the next and so on and so on.

But there’s still a problem. If infected mosquitoes give birth to 99% weakened mosquitoes, then those mosquitoes will simply get bred out by normal individuals from completely separate parents, and the attack will go nowhere. The key to this mosquito “bomb” is that while 99% of offspring get the engineered gene, that gene doesn’t cause any problems when there’s only one copy.

So, try to follow the counting here.

Scientists splice one copy of their experimental gene directly into a germ cell, where it then destroys and replaces the other copy and makes itself into the cell’s sole version of that gene. Then, the germ cell splits into two sperm cells, each of which has one infected copy in its half-sized genome. This infected half-genome then fertilizes a non-infected egg through normal breeding with another mosquito, combining to make a new mosquito with one copy of our synthetic gene, from our infected male’s sperm cell, and one copy of the natural gene, from the uninfected female’s egg cell.

Now, 99% of our infected male’s offspring are infected with a single copy of the gene we inserted, and become carriers who display no adverse effects. Most regular genes spreading through the mosquito population by natural processes have to spread without the Gene Drive ability to power them into 99% of offspring very quickly, meaning that even very advantageous genes won’t be able to spread as fast as our silent, seemingly useless one. With no downside to bias evolution against it, our gene will spread through the population in just a scant few generations.

Eventually, it will reach such a level of saturation in the population that these fully functioning carrier mosquitoes will begin to mate with one another through sheer chance, each donating infected sperm or egg cells 99% of the time, and thus giving rise to virtually all double-infected offspring. It’s these offspring, with both copies of the gene infected from conception, that express the genetic attack. The females of such mating events are completely sterile, while the males are free to continue breeding and passing on the disease.

What this means is that by the time the Gene Drive starts creating a substantial number of sterile, double-infected mosquitoes, the overall population will already have been infected too heavily to breed it out. With Gene Drive to keep the gene spreading in spite of evolution, the process should continue until there are simply no viable female mosquitoes left to breed with. By the Imperial College team’s calculations, this gene drive approach could completely wipe out a population of mosquitoes in as little as 11 generations, or about a year.

To put this into perspective, in this case, this is a genetic modification that wipes out Malaria by wiping out the Mosquito. In human terms you could compare it to wiping out HIV by wiping out humans, and while there are arguments for both sides of the fence the fact that we now have the technology, and the fact, furthermore, that we’ve already used it to create what’s come to be known as the Doomsday Mosquito humanity will find itself in moral and ethical deadlock.

Do you cure the disease that kills millions of people by genetically engineering a species to go extinct? And if we can genetically engineer one species to go extinct then which species is next? Us?

The last one, as terrifying as it might sound isn’t as far fetched as you might think, and governments around the world have already put this “ultimate bioweapon” on their watch list. As our understanding of this technology and this capability advances, and as costs continue to plummet, it is increasingly easy to see how one day a terrorist group could use it to quietly and subtly kill off an entire race, or population, of people. And if you think that that’s a giant leap then worryingly it isn’t.

Thanks to the Human Genome Project we can already identify and categorise individuals with specific traits – everything from the color of their hair to the color of their skin – as well as their evolutionary lineage and thanks to the rise of CRISPR and Synthetic Biology we now have the tools we need to help us create entire artificial genomes from scratch. By 2036, for example, scientists believe that they might even be able to use CRISPR technology to make the worlds first artificial human (ethics allowing, which of course they won’t, or at least ion the short term).

If we have the technology to eliminate an entire species from the face of the Earth – forever, then the only thing preventing us from pulling the genetic trigger is our moral compass and our belief in our ability to control the outcome and the next time there’s a mass extinction event it might not be an asteroid that’s the culprit.

http://www.globalfuturist.org/2016/12/scientists-have-developed-the-ultimate-bioweapon-an-extinction-gene/

The US Military Says That Human Beings Actually Have A Sixth Sense

Arjun WaliaJuly 24, 2017

 

http://www.collective-evolution.com/2017/07/24/the-us-military-says-that-human-beings-actually-have-a-sixth-sense/

In 2014, the Office of Naval Research began a four year research program, costing approximately four million dollars, to examine premonition and intuition. Dr. Peter Squire (above left), Office of Naval Research (ONR) program manager, expressed to Time that:

advertisement - learn more

“We have to understand what gives rise to this so-called ‘sixth sense,’ says Peter Squire, a program officer in ONR’s Expeditionary Maneuver Warfare and Combating Terrorism department. Today’s Navy scientists place less emphasis on trying to understand the phenomena theoretically and more on using technology to examine the mysterious process, which Navy scientists assure the public is not based on superstition. “If the researchers understand the process, there may be ways to accelerate it — and possibly spread the powers of intuition throughout military units,” says Dr. Squire. The Pentagon’s focus is to maximize the power of the sixth sense for operational use. “If we can characterize this intuitive decision-making process and model it, then the hope is to accelerate the acquisition of these skills,” says Lieutenant Commander Brent Olde of ONR’s Warfighter Performance Department for Human and Bioengineered Systems. “[Are] there ways to improve premonition through training?” he asks.

These types of phenomena are referred to as parapsychology (psi), often dubbed as pseudoscience within the mainstream. Not many people are aware of the fact that a number of publications have been published for decades showing statistically significant results.  In 1999, a statistics professor at UC Irvine published a paper showing that parapsychological experiments have produced much stronger results than those showing a daily dose of aspirin helps prevent a heart attack. She also showed that these results are much stronger than the research behind various drugs like antiplatelets, for example.

This is obviously serious legit stuff, especially if it’s being researched within the highest levels government, the Department of Defense. This specific research program came from reports within the field, where soldiers have used intuition for various operations.

“These reports from the field often detailed a ‘sixth sense’ or a ‘Spidey’ sense that alerted them to an impending attack…or that allowed them to respond to a novel situation without consciously analyzing the situation.” Commander Joseph Cohn, a program manager at the naval office, told the New York Times.

Even in the Times article, they admit that “If it saved lives, it was real,” and that “Since 1972, CIA and DoD research indications that premonition, precognition, appears to be weak in some, strong in others, and extraordinary in a rare few.”

This is true, and yes, research into these types of phenomena have been ongoing for a long time. This became most evident this year, as well as in 1995 when the US government released Project Stargate files. The files also show that these initiatives are international in scope.

Here is another one titled “Research into Paranormal Ability To Break Through Spatial Barriers”  that touches upon the same thing. This is elaborated on later in the article.

This particular document, which was declassified through a Freedom of Information Act request (FOIA), outlines specific people with very special abilities and how they’ve been studied by thousands of scientists and governments around the world for a very long time.

The document is on the CIA website, but only seems to be accessible from the Internet Archives, a San Francisco–based nonprofit digital library with the stated mission of “universal access to all knowledge.”

These facts were also outlined in a declassified US Air Force report on teleportation, which was made available through the Federation of American Scientists.

Below is a brief outline of the document:

• In 1979, a major Chinese science journal, Ziran Zachi (Nature Journal), carried a report on “non-visual pattern recognition” in which numerous accounts of exceptional human body function were confirmed. As a result, an unofficial preliminary organization to study this type of thing under the watch of Nature Journal

• In 1980, the Journal and the Chinese Human Body Science Association held a parapsychology (remote viewing, telepathy, psychokinesis, clairvoyance and more) conference in Shanghai with participants from over 20 research institutes and universities

• In 1981, over 100 centres to study children with purported exceptional abilities and mental capabilities were formed with the cooperation of more than 100 formally trained scholars

• In 1982, the Chinese Academy of Sciences sponsored a public hearing in Beijing that more than 4000 scholars attended regarding cases of parapsychological  abilities within humans. They called for “fair but  strictly controlled” tests to lead to a final judgement. After this happened, two Chinese scientists, Chen Hsin and Mei Lei, gave a speech on it at the joint convention of the Parapsychological Association and the Society for Psychical Research held at Cambridge University.Shortly after that in 1983, “a series of PK experiments with the subject Zhang Baosheng were conducted by 19 researchers led by Prof. Lin Shuhang of the physics department of Beijing Teachers college.”After this became known, as written in the document,  “in 1984, Zhang Baosheng became a full-time subject of the military-run psi research team.”

The document outlines how many of these scholars agreed that the scientific evidence for the ‘paranormal’ was not sufficient enough to make any conclusions. The next point is arguably the most important one disclosed in the document.

One of Zhang’s accomplishments involved moving sealed objects in and out of sealed containers. Which is also listed in the document above.
Is this really that far fetched? After all, at the quantum scale, teleportation has already occurred.
The list goes on and on, and it’s quite large.

If You Want To Learn More About This Type of Thing, Listen To Russell Targ

Russell Targ is a physicist and author, a pioneer in the development of the laser and laser applications, and a co-founder of the Stanford Research Institute (SRI) investigation of psychic abilities in the 1970s and 1980s. SRI is a research and development think tank in Menlo Park, California. Called “remote viewing,” his work in the psychic area has been published in Nature, The Proceedings of the Institute of Electronic and Electrical Engineers (IEEE), and the Proceedings of the American Association the Advancement of Science (AAAS).

The paper published in IEEE before the program went classified was titled “A Perceptual Channel For Information Transfer Over Kilometer Distances: Historical Perspectives and Recent Research.” It presented scientific evidence for the existence of a perceptual capacity channel whereby certain individuals are able to perceive and describe remote data not perceivable to any known sense.

He is author or co-author of nine books dealing with the scientific investigation of psychic abilities and Buddhist approaches to the transformation of consciousness.

TED even banned a talk by the co-founder of a 23-year government research program investigating parapsychology at Stanford Research Institute for the CIA, Defense Intelligence Agency, Air Force and Army Intelligence, NASA, and others.

“In this $25 million program we used ‘remote viewing’ to find a downed Russian bomber in North Africa, for which President Carter commended us. We found a kidnapped US general in Italy, and the kidnap car that snatched Patricia Hearst. We looked in on the US hostages in Iran, and predicted the imminent release, who was soon sent to Germany. We described a Russian weapons factory in Siberia, leading to a US congressional investigation about weakness in US security, etc. Our scientific findings were published in Nature, The Proc, IEEE, Proc. AAAS, and Proc. American Institute of Physics. I thought a TED audience would find this recently declassified material interesting. And no physics would be harmed in my presentation.” (source/Cancelled TEDx Talk)

You can view it below: